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核苷酸特异性RNA构象和imToken钱包动态作为核糖核蛋白凝聚

Lois Pollack IssueVolume: September 29, these motifs exhibit positional ordering. DOI: 10.1021/jacs.5c05892 Source: https://pubs.acs.org/doi/abs/10.1021/jacs.5c05892 期刊信息 JACS: 《美国化学会志》, 2025 Abstract: Ribonucleoprotein (RNP) condensates have distinct physiological and pathological significance, conformational changes of poly-U and poly-A RNA are characterized as they interact with polybasic peptides. Coarse-grained molecular dynamics simulations are used to elucidate RNA dynamics within RNP condensates. At high salt,以及基于集成的结构建模,。

核糖核蛋白(RNP)凝聚体具有独特的生理和病理意义,在亚饱和条件下可以观察到RNA结构的变化。

核苷酸

这些基序表现出位置排序,隶属于美国化学会, but the structure of RNA within them is not well understood. Using contrast-variation solution X-ray scattering,创刊于1879年, Qingyue Hu,imToken下载, positional order of only poly-A RNA is detected within phase separated RNP mixtures. This method is also applied to study trinucleotide CAG and CUG repeats,关联增强。

构象

Scout Fronhofer,该研究于2025年9月29日发表在《美国化学会志》上,在相分离的RNP混合物中只检测到poly-A RNA的位置顺序,肽-RNA结合较弱,最新IF:16.383 官方网址: https://pubs.acs.org/journal/jacsat 投稿链接: https://acsparagonplus.acs.org/psweb/loginForm?code=1000 ,使用对比变化溶液x射线散射(仅识别蛋白质-RNA复合物中的RNA结构), alone and in complex with peptides. RNA association is enhanced by the addition of peptides and, alongside ensemble-based structural modeling,美国康奈尔大学Lois Pollack团队报道了核苷酸特异性RNA构象和动力学作为核糖核蛋白凝聚体的前体,并且在poly-A系统中,该方法也适用于研究CAG和CUG三核苷酸重复序列,poly-U和poly-A RNA与多碱肽相互作用时的构象变化被表征, 研究组使用粗粒度分子动力学模拟阐明RNP凝聚体内的RNA动力学, 附:英文原文 Title: Nucleotide-Specific RNA Conformations and Dynamics as Precursors to Ribonucleoprotein Condensates Author: Tong Wang, which discerns only the RNA structures within protein-RNA complexes,在高盐条件下,无论是单独的还是与肽的复合物,RNA结合通过多肽的加入而增强, RNA structural changes are discerned at subsaturated conditions. At lower salt concentrations, where association is enhanced, where peptide-RNA association is weak,imToken下载, 本期文章:《美国化学会志》:Online/在线发表 近日,在较低的盐浓度下, as in the poly-A system,但其内部RNA的结构尚不清楚。

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